Халотестин

 

Halotestin (fluoxymesterone) is a male hormone (androgen) used in men as replacement therapy in conditions associated with symptoms of deficiency or absence of endogenous testosterone, and in delayed puberty. Halotestin may also be used in some women for palliation of androgen-responsive recurrent breast cancer. The brand name Halotestin is discontinued, but generic versions may be available.

Fluoxymesterone is a white or nearly white, odorless, crystalline powder, melting at or about 240 degree C, with some decomposition. It is practically insoluble in water, sparingly soluble in alcohol, and slightly soluble in chloroform.

The chemical name for fluoxymesterone is androst-4-en-3-one, 9-fluoro-11,17- dihydroxy-17-methyl-, (11 ,17 )-. The molecular formula is C20H29FO3 and the molecular weight 336.45.

For complete replacement in the hypogonadal male, a daily dose of 5 to 20 mg will suffice in the majority of patients. It is usually preferable to begin treatment with full therapeutic doses which are later adjusted to individual requirements. Priapism is indicative of excessive dosage and is indication for temporary withdrawal of the drug.

The recommended total daily dose for palliative therapy in advanced inoperable carcinoma of the breast is 10 to 40 mg. Because of its short action, fluoxymesterone should be administered to patients in divided, rather than single, daily doses to ensure more stable blood levels. In general, it appears necessary to continue therapy for at least one month for a satisfactory subjective response, and for two to three months for an objective response.

горячая этикетка :